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Study at Capital Regional Medical Center & Affiliated Hospitals Shows “Universal Decolonization” of ICU Patients Reduces Bloodstream Infections by 44 Percent

Study at Capital Regional Medical Center & Affiliated Hospitals Shows “Universal Decolonization” of ICU Patients Reduces Bloodstream Infections by 44 Percent

November 05, 2012

Tallahassee, FL – Capital Regional Medical Center and 42 affiliated hospitals participated in a comprehensive new study, concluded that using antimicrobial soap and ointment on intensive care unit patients reduces bloodstream infections, including MRSA, by 44 percent.

The use of antimicrobial agents on an entire patient population is referred to as universal decolonization. The study, known as Randomized Evaluation of Decolonization Versus Universal Clearance to Eliminate (REDUCE) MRSA, was conducted in conjunction with investigators at Harvard and several other academic institutions, and research programs at two U.S. Department of Health and Human Services agencies, the Agency for Healthcare Research and Quality (AHRQ) and the Centers for Disease Control and Prevention (CDC).

The results of REDUCE MRSA were released at IDWeek 2012™, an annual meeting of infectious disease organizations that convenes leading researchers to showcase the latest developments in the field. The findings suggest a major change in healthcare practice that could save lives. HCA is rolling out universal decolonization in its adult intensive care units, and implementation is expected to be completed at virtually all HCA affiliates in early 2013.

“The REDUCE MRSA study proved convincingly that universal decolonization is the best practice to prevent infection from MRSA and other antibiotic-resistant bacteria in high risk ICU patients,” said Jonathan B. Perlin, MD, President, Clinical and Physician Services Group and Chief Medical Officer of HCA. “By bathing patients with chlorhexidine antiseptic soap and swabbing their noses with mupirocin antibiotic ointment, central line bloodstream infections caused by MRSA and other antibiotic-resistant bacteria can be reduced. These compelling results convinced us to begin implementing this protocol in HCA hospital ICUs.”

The study, which involved nearly 75,000 patients and more than 280,000 patient days in 74 adult ICUs located in 16 states, compared the results of three approaches in ICUs:

  • Screen all patients and isolate MRSA carriers
  • Targeted decolonization after screening
  • Universal decolonization
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